The Silkmen fell to defeat away at Brunton Park as a Ryan Loft goal completed a Carlisle comeback after Theo Archibald had given Macc a first half lead.
Loft closed down a Fiacre Kelleher clearance before slipping the ball past Owen Evans to condemn Macc to a narrow defeat.
Theo Archibald's opener had put Macc ahead before Carlisle equalised through Harry McKirdy just before the interval.
Macc had the better of the opening exchanges with Corey O’Keeffe doing well to get his shot off on the ten-minute mark, although it lacked the power to trouble Adam Collin in the Carlisle goal.
Our hosts responded five minutes later through a Jack Iredale strike from distance, which Owen Evans saw fly wide of his far post.
Theo Archibald was next to try his luck, but his dipping effort from distance was eventually gathered by Collin despite a threatening looking scenario with Macc attackers closing in for a potential rebound.
Carlisle then had two good chances in quick succession as they looked to open the scoring.
Mohammed Sagaf fired over from inside the Silkmen area despite being afforded what appeared to be enough space to take his time over the shot; before Olufela Olomola saw his header drift just over the Macc crossbar in Carlisle’s best spell of the half.
Archibald then put us in front with a powerful strike into the top corner of the goal after Joe Ironside saw two efforts blocked and then saved by the Carlisle back line.
Macc were awarded a penalty moments later and Ironside took the responsibility, but his spot-kick was saved by Collin.
This proved costly moments before half time as Carlisle equalised in bizarre fashion.
Corey O’Keeffe sliced his clearance from a Carlisle corner and the ball flew into Harry McKirdy and over the line to hand the Cumbrians an unlikely equaliser.
Carlisle used this momentum heading into the second period and started the better of the two sides; with their most dangerous early efforts being blocked in dramatic fashion by Fiacre Kelleher and Miles Welch-Hayes, as Sagaf and McKirdy saw their goal bound efforts cut out.
Macc then came close to regaining the lead, but Ben Stephens was judged to have been offside as he nodded the ball into the net after Theo Archibald’s deflected shot had rebounded off the crossbar.
Carlisle had a golden opportunity to snatch all three points with fifteen minutes remaining, but Hallam Hope nodded a Nathan Thomas cross just wide of Evans’ goal as Carlisle continued to press.
They eventually took the lead with less than ten minutes to play as Ryan Loft closed down Kelleher’s clearance before sliding the ball past Evans.
1. Adam Collin (C)
3. Jack Iredale
5. Jon Mellish
7. Nathan Thomas
8. Mike Jones
11. Harry McKirdy (Hallam Hope 66’)
14. Gethin Jones
19. Jack Bridge (Canice Carroll 84’)
23. Jarrad Branthwaite
24. Olufela Olomola (Ryan Loft 75’)
28. Mohammed Sagaf
Louis Gray (GK), Aaron Hayden, Nathaniel Knight-Percival, Elias Sorensen.
1. Owen Evans
5. Fiacre Kelleher (C)
6. Theo Vassell
9. Joe Ironside (Virgil Gomis 66’)
10. Ben Stephens
11. Theo Archibald
12. Miles Welch-Hayes
14. Connor Kirby
16. Corey O’Keeffe
20. Emmanuel Osadebe
25. Nathan Cameron
Reice Charles-Cook (GK), Eddie Clarke, Fraser Horsfall, Brice Ntambwe, David Fitzpatrick.